MatrixOne to Host Seminars on Streamlining the Product Development and Regulatory Compliance Processes for Medical Device Manufacturers

Medtronic, IntegWare, BioSense Webster, Gateway Group and GE Healthcare to join MatrixOne in presenting timely case studies and presentations in Illinois and California

WESTFORD, Mass.—(BUSINESS WIRE)—March 15, 2006— MatrixOne, Inc. (NASDAQ: MONE), a leading provider of collaborative product lifecycle management (PLM) solutions for the value chain(TM), today announced that it will be hosting two free seminars focused on the product development and regulatory compliance issues affecting medical device manufacturing companies today. The events will take place in Rosemont, Illinois on March 21, 2006 and in Costa Mesa, California on March 28, 2006.

Medical device manufacturers are facing pressure on several fronts: fierce competition among manufacturers often means that the company which gets its product to market first is the winner--but just getting it to market can take forever, between having to manage a global development process and collecting all of the information needed to comply with regulations. In these seminars, issues like these will be dissected, and attendees will learn from real-life examples how software solutions like PLM can put tools in place that make it easier to design high volume medical devices, manage a global development process, ensure consistent quality and shorten the cycle times needed to get a product approved and out to market.

In addition to a discussion of the above issues and a demo of the MatrixOne Accelerator for FDA Compliance(TM)--a single comprehensive solution that enables medical device manufacturers to achieve FDA compliance throughout their product lifecycle processes, drastically reducing product development costs and helping them to deliver products to market quicker than the competition--each event will feature guest speakers that will share their insights on how medical manufacturers can take advantage of PLM:

-- The Illinois event will feature GE Healthcare's PLM architect, Bhuvanesh Sharma, sharing how GE Healthcare manages innovation in a global environment; Dr. Ranier Hoff, president and senior principal consultant for the Gateway Group, will discuss what the critical success factors are for implementing PLM in an environment increasingly regulated by the FDA; and Medtronic's Barbara Ruble, director PLM program office, along with Spring Shi, Medtronic's PLM program strategist, will present a case study on how to enable product innovation with secure supplier collaboration.

-- In California, Bobby Keen, vice president of process excellence at BioSense Webster, a Johnson & Johnson Company, will give a presentation focusing on the pursuit and benefits of process excellence in the medical device industry. He will be joined at the event by Scott Main, vice president at IntegWare, who will share a case study on how to prepare a strategy for the implementation and use of PLM in the medical device industry; and Boris Cononetz, the PLM project manager at Medtronic, who will lead a discussion on the benefits a medical environment can realize from a PLM implementation.
What/When/Where: Two free conferences (complimentary lunch included):

                "Driving Innovation, Quality and Regulatory 
                 Compliance for the Medical Device Industry"
                 Tuesday, March 21, 2006
                 Hyatt Rosemont
                 6350 N. River Road
                 Rosemont, IL 60018

                "Driving Innovation, Quality and Regulatory Compliance
                 in the Global Enterprise"

                 Tuesday, March 28, 2006
                 Hilton Orange County/Costa Mesa
                 3050 Bristol Street
                 Costa Mesa, CA 92626

Who:             Speakers from MatrixOne, Medtronic, IntegWare, 
                 BioSense Webster, Gateway Group and GE Healthcare 
                 will share their knowledge and expertise to help 
                 attendees understand the latest issues facing
                 medical device manufacturers--and learn how these 
                 issues can be solved.

To Register:     Please visit:

                 Please contact with any 

About MatrixOne, Inc.

MatrixOne, Inc. (NASDAQ: MONE), a leading global provider of collaborative product lifecycle management (PLM) software and services, enables companies to accelerate product innovation to achieve top line revenue growth and improve bottom line profitability. With world-class PLM solutions and a commitment to customer success, MatrixOne is focused on helping companies across the automotive, aerospace & defense, consumer, machinery, medical device, semiconductor and high-tech industries solve their most challenging new product development and introduction problems. More than 800 companies use MatrixOne's solutions to drive business value and gain a competitive advantage, including industry leaders such as BAE Systems, Bosch, Comau, General Electric, Honda, Johnson Controls, Linde AG, NCR, New Balance, Nokia, Philips, Porsche, Procter & Gamble, Sony Ericsson, STMicroelectronics and Toshiba. MatrixOne ( is headquartered in Westford, Massachusetts, with locations throughout North America, Europe and Asia-Pacific. On March 1, 2006, Dassault Systemes entered into a definitive agreement to acquire MatrixOne, Inc., subject to customary closing conditions.

MatrixOne and the MatrixOne logo are registered trademarks and "a leading provider of collaborative product lifecycle management (PLM) solutions for the value chain" and the MatrixOne Accelerator for FDA Compliance are trademarks of MatrixOne, Inc. All other trademarks and service marks are the property of their respective owners.

Forward-looking statements in this release are subject to risks and uncertainties that could cause our actual results to differ materially from those anticipated. Such statements may relate, among other things, to our plans, objectives and expected financial and operating results. The risks and uncertainties that may affect forward-looking statements include, among others: poor product sales, long sales cycles, difficulty developing new products, difficulty in relationships with vendors and partners, higher risk in international operations, difficulty assimilating future acquisitions, difficulty managing rapid growth, and increased competition. For more about the risks and uncertainties of our business, see our periodic and other S.E.C. filings.

MatrixOne, Inc.
Sharon Rodger, 978-589-4066

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