The Discovery Of Amgen's Novel Investigational KRAS(G12C) Inhibitor AMG 510 Published In Nature

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The scientific information discussed in this news release related to Amgen's product candidates is preliminary and investigative. Such product candidates are not approved by the U.S. Food and Drug Administration, and no conclusions can or should be drawn regarding the safety or effectiveness of the product candidates.

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  1. Cox A, et al. Drugging the undruggable RAS: Mission possible? Nat Rev Drug Discov. 2014 Nov;13(11):828-51.
  2. Fernandez-Medarde A, Santos E. Ras in cancer and developmental diseases. Genes Cancer. 2011 Mar;2(3):344-58.
  3. Lipford, JR. Pre-clinical development of AMG 510: the first inhibitor of KRASG12C in clinical testing. Oral presentation at AACR 2019, Atlanta, GA. March 29-April 3, 2019.
  4. Stephen AG, et al. Dragging ras back in the ring. Cancer Cell. 2014 Mar 17;25(3):272-81.

 

AMG 510 bound to KRAS G12C. The yellow region depicts where AMG 510 covalently attaches to the KRAS protein.

 

KRAS Infographic

 

Amgen Logo

 

Cision View original content: http://www.prnewswire.com/news-releases/the-discovery-of-amgens-novel-investigational-krasg12c-inhibitor-amg-510-published-in-nature-300948664.html

SOURCE Amgen

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Company Name: Amgen
Web: http://www.amgen.com
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