I have been an Windows and DOS based layout tools for the past 16 years, only a few of the cell generation tools have really worked. I have worked with customers that have had working solutions with the following tools:
IC Editors - .cmd file builders, all custom
Silvaco - Expert layout system and Lisa macro programming language
Mentor - IC Station SDL proprietary language device builder
Avanti (Synopsys) - Cosmos - New tool only one customer that I have worked with
There tools listed are a bunch of other tools on the market, but these are ones that I have built custom designs with that went into production and worked.
I'm not going to claim that they are the best or weren't quirky, but we got the schedule on time and shipped the silicon.